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5α-Reductase Inhibitors and
Other Anti-Dihydrotestosterone Actions
​from Plants

(c) 2026, Eric Yarnell, ND

Unfortunately, there is very little information about what herbs can actually reduce dihydrotestosterone (DHT) levels or activity in humans. The database here discusses the one herb for which we do have limited research on this question, as well as those studied in vitro and in animals with a range of anti-DHT actions. The effective concentrations reported in most in vitro studies are highly unlikely to be achieved in prostate tissue after oral intake of the herbs in questions, but have more potential to be effective applied topically to the scalp to address androgenetic alopecia.
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